Inhibition by cromoglycate of histamine release induced by dextran plus phosphatidyl serine.
نویسندگان
چکیده
REFERENCES LEDINGHAM, I. McA., MCARDLE, C. S. & PARRATT, J. R. (1972). Comparison of a coronary vasodilator drug (carbochromen) and a cardiac stimulant (oxyfedrine) on blood flow and oxygen extraction in experimental myocardial infarcts. Br. J. Pharmac., 44, 323-324P. MARSHALL, R. J. & PARRATT, J. R. (1973). The effect of noradrenaline on blood flow and oxygen consumption in normal and ischaemic areas of myocardium. Br. J. Pharmac., in press.
منابع مشابه
Effect of calcium on dextran-induced histamine release from isolated mast cells.
Phosphatidyl serine potentiation of dextran-induced histamine release from isolated rat mast cells, was found to be calcium-dependent.
متن کاملHistamine and its Releasing Agents
Spontaneous histamine release from isolarted Mastcells was found to be independent of calcium in the concentration range up to 1 m. mole/lit. Phosphatidyl serine do not change the effect of calcium on spontaneous release. The activation of anaphyla.ctic histamine release by calcium is potentiated by phosphatidyl serine but the laitter can't do so w1th strontium. Mastcells, pretreated with AT...
متن کاملThe effect of phospholipids on anaphylactic histamine release.
1. Histamine release by antigen from three sensitized rat tissues is potentiated by phosphatidyl serine (PS). The effect is greatest with isolated peritoneal cells. Phosphatidyl inositol, ethanolamine, choline and phosphatidic acid are inactive.2. PS greatly increases the rate of antigen-induced histamine release and only slightly prolongs the duration of the release process.3. PS shows a conce...
متن کاملThe inhibition of histamine release from guinea-pig lung by compound I.C.I. 74917 and isoprenaline.
Compounds that increase tissue concentrations of cyclic AMP inhibit the release of histamine from sensitized tissues when they are challenged with antigen. It has been proposed that the anti-asthmatic agent disodium cromoglycate exerts its anti-allergic properties by inhibiting cyclic AMP phosphodiesterase. This hypothesis was based on experiments where it was shown that the inhibition of antig...
متن کاملA comparison of the inhibition of phosphodiesterase activity and allergic histamine release by disodium cromoglycate and compound I.C.I. 74917.
Compounds that increase cellular cyclic AMP concentrations, such as isoprenaline, adrenaline and prostaglandin El, inhibit the release of histamine from sensitive tissues after antigen challenge (Assem & Schild, 1969; Lichtenstein & Margolis, 1968). The present paper describes experiments that show that I.C.I. compound 74917, Bufrolin (6-n-butyl-2,8-dicarboxy-4,10-dioxo-1,4,7,1O-tetrahydro-l,7-...
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ورودعنوان ژورنال:
- British journal of pharmacology
دوره 47 3 شماره
صفحات -
تاریخ انتشار 1973